IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery

Completed · Phase 4 · Has a placebo group

Conditions studied: Acute Pain, Hyperalgesia

In brief

Patients undergoing cardiac surgery experience significant postoperative pain, which may impact postoperative outcomes. The aim of this single center, double-blind, randomized, placebo controlled trial is to determine if intravenous (IV) acetaminophen will significantly decrease 24 hour postoperative opioid consumption.

Key facts

Study ID

NCT01544062

Run by

University of Washington

People needed

68

Starts

2012-07-01

Expected to finish

2014-08-01

Last updated by the study team

2016-06-21

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• (1) subjects who clinically consented to elective sternotomy for coronary artery bypass grafting (CABG), heart valve repair or replacement under general anesthesia, and (2) ages between 18 and 75 years

You may not qualify if…

• (1) subject refusal, (2) non-English speaking, (3) previous chronic or neuropathic pain, (4) previous chronic use of opioids, (5) history of psychiatric disorder, (6) allergy to acetaminophen, (7) severely impaired liver and kidney function and (8) previous sternotomy

Where it is running

• University of Washington Medical Center, Department of ANesthesiology and Pain Medicine — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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