Oxidative Stress, Inflammation and Acute Decompensation in Urea Cycle Disorders
Stopped early
Conditions studied: Urea Cycle Disorders
In brief
The primary purpose of the proposed study is to characterize the oxidative stress and inflammatory cytokine status in UCD during baseline and decompensated states.
Key facts
- Study ID
- NCT01541722
- Run by
- Mark Batshaw
- People needed
- 10
- Starts
- 2012-02-01
- Expected to finish
- 2015-07-01
- Last updated by the study team
- 2015-10-02
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Confirmed or highly-likely diagnosis of one of the eight UCDs as established for the Longitudinal Study (5101) (See section 4.2 Inclusion Criteria, Table 4 for diagnostic criteria for patients with UCD)
- Enrolled in Longitudinal Study of Urea Cycle Disorders (RDCRN UCDC #5101)
You may not qualify if…
- UCD patients who have undergone orthotopic liver transplantation
- Significant chronic medical co-morbidity that might confound the analysis as determined by the site investigators.
- Significant co-morbidities include but are not limited to:
- diabetes, liver failure + cirrhosis
- renal failure
- cardiac disease
- chronic inflammatory diseases
- asthma requiring daily long-term control medications
- significant respiratory disease.
Where it is running
- University of California, Los Angeles — Los Angeles, California, United States
- The Children's Hospital, Aurora — Aurora, Colorado, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- Mount Sinai School of Medicine — New York, New York, United States
- Case Western Medical College — Cleveland, Ohio, United States
- Oregon Health and Science University — Portland, Oregon, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Baylor College of Medicine — Houston, Texas, United States
- Children's Hospital and Regional Medical Center — Seattle, Washington, United States
- The Hospital for Sick Children — Toronto, Ontario, Canada
Full record on ClinicalTrials.gov
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