Safety Study of Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody in Lupus Nephritis

Stopped early · Phase 1

Conditions studied: Systemic Lupus Erythematosus

In brief

The purpose of this study is to determine the safety and tolerability of Anti-MIF Antibody in subjects with lupus nephritis.

Key facts

Study ID

NCT01541670

Run by

Baxalta now part of Shire

People needed

4

Starts

2011-11-28

Expected to finish

2012-12-31

Last updated by the study team

2021-05-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed and dated written informed consent obtained from the subject
• Males and females of age 18 years and older at the time of screening
• Established diagnosis of systemic lupus erythematosus (SLE) according to the American College of Rheumatology classification criteria
• Documented renal biopsy evidence of proliferative glomerulonephritis prior to screening
• Urine protein-to-creatinine ratio > 0.5 (mg/mg)

You may not qualify if…

• Any significant health problem other than lupus or lupus nephritis

Where it is running

• Academic Medical Research Institute Inc. — Los Angeles, California, United States
• Mohamed A. El-Shahawy — Los Angeles, California, United States
• North Valley Nephrology — Yuba City, California, United States
• IMMUNOe International Research Centers — Centennial, Colorado, United States
• University of Colorado — Denver, Colorado, United States
• Tulane University Hospital & Clinic — New Orleans, Louisiana, United States
• Clinical Research Development Associates, LLC — Springfield Gardens, New York, United States
• Northeast Clinical Research Center, LLC — Bethlehem, Pennsylvania, United States
• Medical University of South Carolina (MUSC) — Charleston, South Carolina, United States
• Ramesh Gupta — Memphis, Tennessee, United States
• Ramesh Gupta — Memphis, Tennessee, United States
• UT Southwestern Medical Center at Dallas — Dallas, Texas, United States
• Austin Health — Heidelberg, Victoria, Australia
• The Alfred Hospital — Melbourne, Victoria, Australia
• Linear Clinical Research Limited — Nedlands, Western Australia, Australia
• CHUM Hôpital Saint-Luc — Montreal, Quebec, Canada
• St. Paul´s Hospital — Saskatoon, Saskatchewan, Canada
• Mexico Center for Clinical Research S.A de C.V — Mexico City, Mexico City, Mexico
• Hospital y Clinica OCA SA de CV — Monterrey, Nuevo León, Mexico
• Hospital Universitario Dr Jose Eleuterio Gonzalez — Monterrey, Nuevo León, Mexico
• Clinica San Jose — Sonora, Obregon, Mexico
• Hospital CIMA Chihuahua — Chihuahua City, Mexico
• Auckland City Hospital — Auckland, New Zealand
• Middlemore Hospital — Auckland, New Zealand

Full record on ClinicalTrials.gov

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