Does Class of Dietary Fat Affect Insulin Resistance?

Completed · Not applicable

Conditions studied: Insulin Resistance

In brief

It has been shown that intravenous fatty acids given to normal volunteers in the form of heparin and lipid emulsions will cause insulin resistance in a matter of a few hours. It is not known if this same phenomenon can be demonstrated with oral fat. The investigators are specifically interested in whether or not there are differences in the induction of insulin resistance between the 3 main classes of fatty acids (saturated, monounsaturated and polyunsaturated). The investigators also plan to evaluate endothelial dysfunction and blood pressure; both of which frequently accompany insulin resistance.

Key facts

Study ID

NCT01541592

Run by

Mayo Clinic

People needed

24

Starts

2012-03-01

Expected to finish

2014-02-01

Last updated by the study team

2014-11-26

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Lean,healthy adults 18 - 40
• No chronic medications (birth control pills allowed)
• Weight stable
• Normal fasting labs performed at screening
• Body mass index ≤ 25 kg/M\^2 .

You may not qualify if…

• Insulin dependent diabetes
• Thyroid disease
• History of diabetes or heart disease
• History of type 2 diabetes in parent or sibling

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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