Weaning From Prolonged Mechanical Ventilation

Completed · Not applicable

Conditions studied: Acute Mechanical Ventilatory Failure

In brief

Patients requiring the use of artificial ventilation (also called mechanical ventilation) for more than 21 days account for more than 37% of all ICU costs. As such, these patients are now transferred to centers that specialize in weaning patients from the respirator; these units are referred to as long-term acute care (LTAC) facilities. Despite the increase of LTAC facilities, research on the fastest method for disconnecting the patient from the respirator is lacking. In addition, little information is available regarding the long-term survival and quality of life after a prolonged course of artificial ventilation. The purpose of this study is to determine the fastest method for disconnecting the patient from the respirator at a LTAC facility and its effect on long-term survival and quality of life.

Key facts

Study ID

NCT01541462

Run by

RML Specialty Hospital

People needed

500

Starts

2000-10-01

Expected to finish

2011-10-01

Last updated by the study team

2012-03-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Mechanical Ventilation for at least 21 days

You may not qualify if…

• Hypoxemia (oxygen saturation < 90% with fractional inspired O2 concentration > 0.40, and positive end-expiratory pressure > 5 cm H2O
• Hemodynamic instability (requiring intravenous vasoactive agents, such as dopamine > 5 mg/kg/min)
• Profound neurological deficits (large stroke)
• Documented bilateral phrenic nerve injury
• Previous admission to RML Hospital
• Life expectancy less than 3 months

Where it is running

• RML Specialty Hospital — Hinsdale, Illinois, United States

Full record on ClinicalTrials.gov

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