Studying Biomarkers as a Diagnostic Tool in Samples From Younger Patients With B-Cell Acute Lymphoblastic Leukemia

Completed

Conditions studied: B-cell Childhood Acute Lymphoblastic Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission, Recurrent Childhood Acute Lymphoblastic Leukemia

In brief

This clinical trial is studying biomarkers as a diagnostic tool in samples from younger patients with B-cell acute lymphoblastic leukemia. Finding specific biomarkers may help improve the treatment of patients with B-cell acute lymphoblastic leukemia

Key facts

Study ID

NCT01540578

Run by

Children's Oncology Group

People needed

70

Starts

2012-02-01

Last updated by the study team

2016-05-18

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Frozen viable cell samples from patients with B-cell acute lymphoblastic (ALL) of any outcome from the Children's Oncology Group (COG) ALL Cell Bank (Part 1)
• Freshand frozen cell samples from patients with B-cell ALL with known outcomes from the COG ALL Cell Bank (Part 2) meeting 1 of the following criteria:
• Samples from patients who experienced an early recurrence within 36 months of diagnosis (cases)
• Samples from patients who remain in prolonged remission (controls)
• No samples meeting either of the following criteria:
• Very-high-risk features
• Philadelphia chromosome positive
• Hypodiploid
• MLL (11q23) rearranged
• Known favorable risk factors
• Hyperdiploid
• t(12;21) (ETV6/RUNX1)

Where it is running

• Children's Oncology Group — Monrovia, California, United States

Full record on ClinicalTrials.gov

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