The Effects of Antihistamines on Pre-Pulse Inhibition

Completed · Phase 1 · Has a placebo group

Conditions studied: Healthy

In brief

The purpose of the investigators research is to test whether problems people have with processing their senses (feeling overwhelmed, distracted or upset by sounds and other stimuli) can be lessened by meclizine, a drug found in many over the counter antihistamines, which are medicines used for things like allergies, sleep problems, or the common cold.

Key facts

Study ID

NCT01537471

Run by

Duke University

People needed

117

Starts

2012-01-01

Expected to finish

2012-09-01

Last updated by the study team

2013-01-16

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-40 males or females
• Startle response >0.5
• PPI < 32
• CO level <8ppm

You may not qualify if…

• Tobacco or nicotine use within 2 weeks of screening
• Current or history of a neurological disorder of neurological event
• Negative response to antihistamine use in past
• ECT treatment in the past 6 months
• Current or past history of manic or hypomanic episodes (SCID-I)
• Current or history of psychotic disorder
• Current alcohol or substance abuse/dependence
• Positive urine drug test
• CO level of >8ppm
• Startle <0.5 \& overall PPI >32 (assessed during study)
• Significant hearing problem

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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