Oral Ondansetron Versus Transdermal Granisetron (Sancuso) for Women With Cervical, Endometrial or Vaginal Cancer Receiving Pelvic Chemoradiation
Completed · Phase 3
Conditions studied: Cancer of the Cervix
In brief
The goal of this clinical research study is to compare granisetron (when given through a patch) to ondansetron (when taken by mouth) for reducing nausea and vomiting in women with cervical, endometrial, or vaginal cancer having chemoradiation. Granisetron and ondansetron are designed to help reduce nausea and vomiting.
Key facts
- Study ID
- NCT01536392
- Run by
- M.D. Anderson Cancer Center
- People needed
- 76
- Starts
- 2012-03-01
- Expected to finish
- 2019-10-03
- Last updated by the study team
- 2021-06-11
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Women with cervical, endometrial or vaginal cancer dispositioned to receive primary or postoperative adjuvant pelvic radiation therapy with concurrent cisplatin administration.
- Women must be at least 18 years of age.
- Women must be able to read English or Spanish at a sixth grade level.
- Women with childbearing potential must have a negative pregnancy test within 1 week of starting chemoradiation therapy.
You may not qualify if…
- Women with cervical, endometrial or vaginal cancer who are receiving chemotherapy and/or radiation therapy for recurrent disease.
- Women with cervical, endometrial, or vaginal cancer who are receiving extended field radiation therapy.
- Women with cervical, endometrial or vaginal cancer who are receiving chemotherapy and/or radiation therapy in a palliative setting.
- Women with cervical, endometrial, or vaginal cancer who have already received their first dose of chemotherapy or radiation for more than 7 days prior to starting chemotherapy.
Where it is running
- Lyndon B. Johnson General Hospital — Houston, Texas, United States
- University of Texas MD Anderson Cancer Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
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