Assessment of Eloquent Function in Brain Tumor Patients

Recruiting now

Conditions studied: Primary Brain Tumor, Metastatic Brain Tumor

In brief

Purpose of the study: AIM 1: Prospectively collect pre-operative \[functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), magnetoencephalography (MEG)\] and intra-operative mapping data in patients with intra-axial brain tumors to assess how well each modality predicts the location of eloquent brain function. In addition, each modality will be compared with the other. AIM 2: Assess reorganization of eloquent brain function and plasticity in patients with intra-axial brain tumors. This will be accomplished by prospectively collecting post-operative mapping studies and neuropsychological tests to compare them to prior mapping studies as stated above.

Key facts

Study ID

NCT01535430

Run by

University of Nebraska

People needed

75

Starts

2012-01-31

Expected to finish

2027-12-01

Last updated by the study team

2026-01-13

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 19 years and older
• Brain tumor in or near eloquent brain regions that is appropriate for attempted resection
• Appropriate body habitus and mental status/capacity to participate with non-invasive or invasive mapping
• Benign or malignant intra-axial brain tumor
• Primary or metastatic intra-axial brain tumor

You may not qualify if…

• Any contraindication to MRI (i.e. implanted devices)
• Inappropriate body habitus or mental status/capacity to participate with non-invasive or invasive mapping in a safe and reliable manner
• Declining to participate
• Lacks capacity to understand the study or consent for themselves
• Neurologic status which precludes testing (poor function- not testable)
• Positive pregnancy test
• End stage renal disease or severe renal dysfunction

Where it is running

• University of Nebraska Medical Center — Omaha, Nebraska, United States (enrolling)

Full record on ClinicalTrials.gov

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