Stem Cell Study of Genetics and Drug Addiction
Completed
Conditions studied: Induced Pluripotent Stem Cells
In brief
Background: \- Researchers are interested in studying the roles that genes play in drug and alcohol addiction. Genes seem to account for about half of the differences between people who become addicted to drugs and people who do not. This study will collect blood and skin cell samples. These cells will be used to develop stem cells that are useful for studying how genes are related to drug use and dependence. Objectives: \- To study genetic and cellular differences between people who are addicted to drugs and those who are not. Eligibility: * Individuals between 21 and 65 years of age who do not use drugs. * Individuals between 21 and 65 years of age who are in treatment with buprenorphine or methadone. Design: * Participants will be screened with a brief physical exam and medical history. * Participants will also answer questions about physical and mental health, quality of life, and history of drug and alcohol use. A urine sample and cheek swab sample will be collected. * Participants whose genetic samples match the study requirements will be asked to come back to provide a skin biopsy sample and a second urine sample.
Key facts
- Study ID
- NCT01534624
- Run by
- National Institute on Drug Abuse (NIDA)
- People needed
- 49
- Starts
- 2012-02-07
- Expected to finish
- 2014-07-30
- Last updated by the study team
- 2019-12-17
Who can join
Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Relevant neurological disorders (including, but not limited to, Parkinson s disease and Huntington s disease).
- contraindications to skin biopsy including, but not limited to, bleeding disorders, skin disorders, and immune disorders, that the MAI determines may alter the risk of the biopsy.
- cognitive impairment severe enough to preclude informed consent or valid responses on questionnaires.
- controls will also be excluded if they test positive for drugs or alcohol during screening or study visits.
- unwillingness to allow samples to be kept for future research.
Where it is running
- National Institute on Drug Abuse — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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