Effects of Juice Plus+® Supplementation on Endothelial Function in Overweight Men

Completed · Not applicable · Has a placebo group

Conditions studied: Overweight and Obesity

In brief

The purpose of the study is to determine the effects of daily ingestion of Juice Plus+® capsules containing Orchard, Garden and Vineyard blends on endothelial function and biomarkers of oxidative stress (oxidized LDL, lipid hydroperoxides and protein carbonyls) in overweight men as compared to the placebo group.

Key facts

Study ID

NCT01533987

Run by

Griffin Hospital

People needed

70

Starts

2009-07-01

Expected to finish

2010-08-01

Last updated by the study team

2012-02-16

Who can join

Age: 18 and older, up to 75. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Male age 25-75 years
• Healthy (no known diabetes mellitus, cardiovascular disease, or eating disorder)
• Non-smoker
• Overweight (BMI ≥25) with central adiposity as indicated by waist circumference (≥102 cm).
• Endothelial dysfunction with high-fat meal

You may not qualify if…

• Use of lipid-lowering or antihypertensive medications, unless stable on medication for at least 3 months and willing to refrain from taking medication for 12 hours prior to EF scanning;
• Regular use of multivitamins and/or complementary or alternative supplement therapy (including all Juice Plus+® products) and unwillingness to discontinue supplementation for at least 8 weeks prior to study initiation and for study duration
• Anticipated inability to complete or comply with study protocol;
• Diagnosed eating disorder
• Any rheumatologic disease requiring regular use of NSAIDs or alternative medications
• Regular use of fiber supplements
• Use of insulin, glucose sensitizing medication, or vasoactive medication
• Substance abuse (chronic alcoholism, or other chemical dependency
• Pre-existing cardiovascular disease.

Where it is running

• Yale-Griffin Prevention Research Center — Derby, Connecticut, United States

Full record on ClinicalTrials.gov

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