CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment
Completed
Conditions studied: Cystic Fibrosis
In brief
The investigators will collect samples of sputum from healthy volunteers and patients with cystic fibrosis for the purpose of: a) purifying airway mucins for plate-based binding studies and; b) assessment of the effects of carbohydrates on the rheologic properties of the sputum. This study has two hypotheses: 1. Lectins from Pseudomonas aeruginosa and Aspergillus fumigatus bind to airway mucins in a fucose-dependent manner, and this binding can be inhibited by fucosyl glycomimetic compounds. 2. Fucosyl glycomimetics will compete with Pseudomonas aeruginosa lectin (PA-IIL) and Aspergillus fumigatus lectin (AFL) and disrupt lectin-driven mucin cross-linking in CF sputum.
Key facts
- Study ID
- NCT01533636
- Run by
- University of California, San Francisco
- People needed
- 114
- Starts
- 2012-07-17
- Expected to finish
- 2026-02-04
- Last updated by the study team
- 2026-02-10
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy control subjects:
- Age 18-65
- No history of lung disease
- Cystic fibrosis subjects:
- Age 18-65
- No history of lung disease other than cystic fibrosis
- Diagnosis of CF if sweat chloride values > 60 mM on two separate pilocarpine iontophoresis sweat tests and/or two allelic CF-producing mutations in genetic analysis
You may not qualify if…
- Use of recreational drugs within 30 days prior to enrollment
- Use of tobacco within 30 days prior to enrollment, or > 10 pack-year tobacco history
- Pregnant or lactating females
Where it is running
- University of California, San Francisco — San Francisco, California, United States
Full record on ClinicalTrials.gov
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