Comparison of Two Naloxone Infusion Rates on the Postoperative Recovery of Patients Undergoing Spine Fusion Surgery

Completed · Not applicable

Conditions studied: Pain, Postoperative, Postoperative Nausea and Vomiting, Scoliosis

In brief

There will be two groups in this study: one group will be given the standard infusion of naloxone, a drug which helps reduce side effects from opioids needed after surgery, and the other group will receive a higher dose. The trial is designed to determine if a higher dose of naloxone infusion will reduce side effects from opioid therapy in patients who have undergone spine fusion for scoliosis.

Key facts

Study ID

NCT01531439

Run by

Children's Mercy Hospital Kansas City

People needed

84

Starts

2011-11-01

Expected to finish

2016-12-01

Last updated by the study team

2020-09-10

Who can join

Age: 10 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Idiopathic scoliosis requiring spine fusion surgery
• Age 10-21 years

You may not qualify if…

• Inability to understand PCA instructions
• Allergy to: morphine, hydromorphone, fentanyl, naloxone, or diphenhydramine
• Chronic opioid therapy > 2 months
• Non-English speaking

Where it is running

• Children's Mercy Hospital — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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