RAPID: Reducing Pain; Preventing Depression

Completed · Phase 4

Conditions studied: Knee Osteoarthritis

In brief

The primary question addressed by this prevention study is to explore if improving pain and disability reduces episodes of Major Depression among seniors with knee osteoarthritis (OA) and mild depressive symptoms.

Key facts

Study ID

NCT01530204

Run by

University of Pittsburgh

People needed

135

Starts

2011-07-01

Expected to finish

2016-03-01

Last updated by the study team

2018-07-03

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• >/= age 60
• meets accepted clinical criteria for knee OA based on the American College of Rheumatology 1986 clinical criteria guidelines.
• Western Ontario and McMaster University Arthritis Index (WOMAC) pain subscale score in the range of 7-15 (to minimize including subjects with knee OA so severe they may be better served by arthroplasty)
• PHQ-9 scores 1-9, with at least one of the cardinal symptoms of depression (low mood or anhedonia) endorsed.
• Modified Mini Mental State (3MS) Examination >/= 80.
• Has or is willing to establish care with a personal physician prior to any experimental procedures.

You may not qualify if…

• Major Depressive Episode or anxiety disorder within the past 1 year
• Currently taking an antidepressant
• History of bipolar or schizophrenia
• Drug or alcohol use disorder within the past 12 months
• Receiving knee-related workers compensation or involved in knee pain-related litigation.
• Currently taking an anti-anxiety medicine > 4 times/week for the past 4 weeks.

Where it is running

• University of Pittsburgh Late Life Depression Program — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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