Platelet Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain

Completed · Not applicable

Conditions studied: Periodontitis

In brief

The aim of the study was to evaluate the safety and effectiveness of Platelet Derived Growth Factor (PDGF) mixed with b tricalcium phosphate (BTCP) for the treatment of advanced periodontal osseous defects at 6 months of healing.

Key facts

Study ID

NCT01530126

Run by

University of Michigan

People needed

180

Starts

2000-01-01

Expected to finish

2007-01-01

Last updated by the study team

2016-01-08

Who can join

Age: 25 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• probing depth of 7mm or greater at baseline
• following debridement, 4mm or greater vertical bone defect depth with at least one intact bony wall
• sufficient keratinized tissue to allow complete tissue coverage of the defect
• a radiographic base of the defect at least 3mm coronal to the apex of the tooth
• no evidence of localized aggressive periodontitis
• smoke less than 1 pack of cigarettes per day

You may not qualify if…

• failure to maintain adequate oral hygiene
• pregnant women or women intending to become pregnant
• history of oral cancer within last 6 months or HIV
• history within last year of periodontal surgery on study tooth
• study tooth mobility greater than 2
• study tooth exhibiting a class 3 furcation defect
• signs of untreated acute infection at the surgical site, apical pathology, root fracture, severe root irregularities, cemental pearls, cementoenamel junction (CEJ) projections not easily removed, untreated carious lesions at the CEJ or on the root surface, subgingival restorations or restorations with open margins at or below CEJ
• history within 6 months of weekly or more frequent use of smokeless chewing tobacco, pipe or cigar smoking, or more than 20 cigarettes a day
• allergy to yeast derived products
• investigational therapy within 30 days of surgery

Where it is running

• University of Michigan School of Dentistry — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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