Fractional Laser vs. Ultrasound for Periorbital Wrinkles

Completed · Early Phase 1

Conditions studied: Wrinkles

In brief

The primary objective of this study is to compare the efficacy of intense focused ultrasound and carbon dioxide-fractionated laser for treatment of periorbital wrinkles.

Key facts

Study ID

NCT01529983

Run by

Northwestern University

People needed

20

Starts

2012-02-01

Expected to finish

2024-05-30

Last updated by the study team

2026-07-01

Who can join

Age: 35 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 35-60 years old male and female subjects with moderate lower eyelid rhytids and crowsfeet
• Subjects with Fitzpatrick skin type I-III.
• Subjects who are willing, have the ability to understand and provide informed consent, and are able to communicate with the investigator.

You may not qualify if…

• Subjects who have received injectable soft-tissue augmentation materials to the face, or facial ablative resurfacing, within the past 6 months.
• Subjects who were received injectable botulinum toxin to the face, or any nonablative laser treatment to the face, within the past 3 months.
• Subjects who have local infections, open facial wounds, or other significant local skin disease that would interfere with periorbital treatment with energy devices.
• Subjects who are allergic to lidocaine or prilocaine.
• Subjects who have a history of abnormal scarring in the treatment area.
• Subject who have ectropion or or other eyelid disfigurement.
• Subjects who have history of isotretinoin use in the preceding year
• Pregnant or lactating individuals

Where it is running

• Northwestern University Feinberg School of Medicine, Department of Dermatology — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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