Vitamin D Metabolism in Chronic Kidney Disease Patients

Status unconfirmed · Not applicable

Conditions studied: Vitamin D Metabolism is in Chronic Kidney Disease

In brief

To determine whether or not chronic kidney disease (CKD), stages III-V and ESRD , is associated with altered vitamin D metabolism related to fibroblast growth factor-23 (FGF-23) stimulation of Cyp24 and whether they have resistance to elevations of 25 Hydroxyvitamin D (25(OH)D3) after cholecalciferol supplementation. To determine if such resistance is related to enhanced catabolism of (25(OH)related to elevated levels of FGF-23.

Key facts

Study ID

NCT01528176

Run by

Memphis VA Medical Center

People needed

70

Starts

2010-11-01

Expected to finish

2012-12-01

Last updated by the study team

2012-02-14

Who can join

Age: 18 and older, up to 85. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• age 18-85 years; CKD stage III or V; serum 25(OH)D level ≤ 30ng/ml, and serum PTH levels > 70 pg/ml within the last 6 months, informed Consent.

You may not qualify if…

• A history of liver disease, sarcoidosis, intestinal malabsorption;
• requirement of dialysis during the study; serum calcium level >10.5 mg/dl,
• calcium-phosphorus product > 70, or
• calcimimetics, or
• phosphorus binders; or
• medications that could affect vitamin D metabolism or
• history of parathyroidectomy.

Where it is running

• Memphis Veteran Affair Medical center — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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