Effect of Chronic Consumption of a Cranberry Beverage on Inflammation and Oxidative Stress
Completed · Not applicable · Has a placebo group
Conditions studied: Inflammation
In brief
The objective of this randomized, double-blind, placebo-controlled, parallel-design clinical trial is to investigate the potential antioxidant benefits of a cranberry beverage. The investigators hypothesize the chronic consumption of this beverage will improve indices of oxidative stress, inflammation, endothelial function, and glucoregulation. The investigators also hypothesize that these benefits will be particularly evident following an oral glucose tolerance test.
Key facts
- Study ID
- NCT01527617
- Run by
- Tufts University
- People needed
- 79
- Starts
- 2012-02-01
- Expected to finish
- 2013-02-01
- Last updated by the study team
- 2016-06-02
Who can join
Age: 30 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men \& women, aged 30-70 years
- BMI 27-34.9 kg/m2
- waist:hip ratio > 0.8 for women and > 0.9 for men
You may not qualify if…
- Cigarette smoking and/or nicotine replacement use within last 6 months
- Individuals taking estrogen or testosterone
- Use of cholesterol-lowering medications
- Use of blood pressure-lowering medications
- Regular use (> 1x/wk) of any stomach acid-lowering medications or laxatives (including fiber supplements)
- Cardiovascular (heart) disease
- Gastrointestinal disease
- Kidney disease
- Endocrine disease: including diabetes, untreated thyroid disease
- Rheumatoid arthritis
- Immune deficiency conditions
- Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- Systolic blood pressure > 139 mmHg and/or diastolic blood pressure > 89 mmHg
- Regular use of systemic steroids, oral or injectable
- Regular daily intake of ≥ 2 alcoholic drinks
- Infrequent (< 3/week) or excessive (> 3/d) number of regular bowel movements
- Gain or loss of ≥ 5% of body weight in the last 6 months
- Pregnancy
- Strict vegetarians
- No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) homeopathic remedies, probiotics, or fish oil (including cod liver oil), for one month prior to study admission
Where it is running
- Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University — Boston, Massachusetts, United States
- Washington State University — Pullman, Washington, United States
Full record on ClinicalTrials.gov
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