Improving Learning-based Treatment of Cocaine Dependence With Medication

Completed · Phase 2 · Has a placebo group

Conditions studied: COCAINE-RELATED DISORDERS

In brief

This study will test the efficacy of d-cycloserine in enhancing response to learning-based treatment for cocaine dependence, specifically contingency management.

Key facts

Study ID

NCT01526538

Run by

Johns Hopkins University

People needed

52

Starts

2011-09-01

Expected to finish

2013-03-01

Last updated by the study team

2017-02-15

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-60 years of age (> 60 due to age-related effects on cognitive functioning)
• Satisfy DSM-IV criteria for cocaine dependence (primarily crack)
• Able to complete all study measures
• Currently seeking treatment for cocaine dependence

You may not qualify if…

• Meets DSM-IV criteria for dependence on a drug other than cocaine or nicotine (may meet abuse criteria for other drugs)
• Pregnant, breast feeding, or planning to become pregnant within 3 months
• If female, do not agree to use an effective means of birth control during the course of treatment (via phone screen)
• History of seizure disorder, severe hepatic impairment, porphyria, serious head trauma, dementia, or significant cognitive impairment
• Diagnosis of current major psychiatric disorder besides substance dependence or abuse
• Reported use of DCS in the past year
• Illiteracy, as will be determined during in-person screening
• Concurrently prescribed or using ethionamide or isoniazid (both used to treat tuberculosis)
• Positive urine result for opioids at screening interview

Where it is running

• Behavioral Pharmacology Research Unit — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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