A Randomized Clinical Trial of Hydrocortisone Augmentation of Prolonged Exposure

Status unconfirmed · Not applicable · Has a placebo group

Conditions studied: Post Traumatic Stress Disorder

In brief

This study seeks to examine the efficacy of hydrocortisone administration in the augmentation of the therapeutic effects of Prolonged Exposure (PE) therapy, an empirically tested treatment shown to be effective in the the treatment of posttraumatic stress disorder (PTSD). The augmentation builds on both the translation of neuroscience findings demonstrating the effects of glucocorticoids (GCs) on learning, and on empirical clinical findings from other investigators demonstrating beneficial effects of GCs in reducing traumatic memories in trauma-exposed persons.

Key facts

Study ID

NCT01525680

Run by

Bronx VA Medical Center

People needed

60

Starts

2011-04-01

Last updated by the study team

2013-11-28

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 to 89
• Capable of understanding, reading, and writing in English
• OIF/OEF veteran with criterion-A trauma while deployed
• Minimum PTSD severity of 60 (CAPS)
• Unmedicated or on a stable psychotropic regimen (i.e., 1 or more months on the same regimen)

You may not qualify if…

• Lifetime history of psychotropic disorder, bipolar disorder, or obsessive compulsive disorder
• Moderate or severe traumatic brain injury (TBI)
• A medical or mental health problem other than PTSD that requires immediate clinical attention
• Substance abuse or dependence within the last 3 months
• Suicidal risk (as determined by response of 5 or 6 on the suicidality items of the Montgomery-Asberg Depression Rating Scale (MADRS)) and/or assessed suicide risk on the basis of clinical judgment
• Persons on a psychotropic medication regimen that has not been consistent for one month
• Presence of diabetes mellitus or any current unstable medical illness or condition that represents a contraindication to taking glucocorticoids (this will be determined by history and/or abnormal laboratory findings at medical clearance)
• Unwillingness to discontinue other specialized psychotherapy for PTSD during the 11 weeks of study treatment and the 3 month follow-up (Self-help (non-trauma focused) groups or supportive counseling can be continued but not initiated)
• Pregnant women or those planning to become pregnant within the study period will not be enrolled. Female participants must agree to use an effective method of birth control (i.e., oral contraceptive, Norplant, diaphragm, condom, or spermicide, abstinence) during the course of the study to ensure they do not become pregnant during the course of the study

Where it is running

• James J. Peters Veterans Affairs Medical Center — The Bronx, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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