Gemcitabine and Oxaliplatin in the Management of Metastatic Pancreatic Cancers With Low Expression of ERCC1
Withdrawn before enrolling · Phase 2
Conditions studied: Metastatic Pancreatic Cancer, ERCC1
In brief
The goal of this clinical trial is to improve and personalize pancreatic cancer care to deliver the most effective therapy while avoiding unnecessary exposure to potential side effects. Excision repair cross-complementation group 1 (ERCC1) protein and mRNA expression predicts response to oxaliplatin - patients whose cancers make small amounts of ERCC1 are much more likely to respond to cisplatin than those whose tumors produce large amounts. The hypothesis is that the combination of gemcitabine and oxaliplatin is a uniquely effective regimen for patients with metastatic pancreatic cancer whose tumors have a low expression of ERCC1.
Key facts
- Study ID
- NCT01524575
- Run by
- University of Hawaii
- People needed
- 0
- Starts
- 2012-01-01
- Expected to finish
- 2014-01-01
- Last updated by the study team
- 2019-09-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically or cytologically confirmed metastatic pancreatic adenocarcinoma
- Patients must not have had prior chemotherapy or biologic therapy for metastatic pancreatic cancer
- Prior adjuvant chemotherapy for completely resected disease or chemoradiotherapy for locally advanced disease is allowed but must have been administered > 6 months prior to registration
- ECOG Performance Status of 0, 1, or 2
- Adequate hematologic, hepatic and renal function
You may not qualify if…
- Pregnant or nursing women
- No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or any other cancer from which the patient has been disease-free for 5 years
- Patients must not have known brain metastases
- Any other condition that in the opinion of the Investigator may render the patient at excessive risk for treatment complications
Where it is running
- University of Hawaii — Honolulu, Hawaii, United States
Full record on ClinicalTrials.gov
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