Study of Mitomycin-C Application in Laryngotracheal Stenosis

Stopped early · Not applicable · Has a placebo group

Conditions studied: Laryngeal Stenosis, Subglottic Stenosis, Tracheal Stenosis

In brief

This is a randomized, prospective, double-blind, placebo-controlled clinical trial of the use of mitomycin-C topical application as an adjunctive treatment in the endoscopic surgical treatment of patients with laryngotracheal stenosis. We hypothesize that the use of mitomycin-C improves patient outcome in the endoscopic surgical treatment of laryngotracheal stenosis.

Key facts

Study ID

NCT01523275

Run by

University of California, San Francisco

People needed

15

Starts

2012-08-01

Expected to finish

2018-02-01

Last updated by the study team

2019-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with laryngotracheal stenosis, including subglottic stenosis or tracheal stenosis
• Patients with disease amenable to treatment with endoscopic CO2 laser radial incisions and balloon dilation
• Age greater than or equal to 18 years

You may not qualify if…

• Age less than 18 years
• Pregnancy
• Patients with glottic and supraglottic stenosis
• Patients with disease not amenable to treatment with endoscopic CO2 laser radial incisions and balloon dilation
• Patients with cartilaginous subglottic or tracheal stenosis

Where it is running

• UCSF - Voice and Swallowing Clinic — San Francisco, California, United States

Full record on ClinicalTrials.gov

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