Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation

Completed · Phase 2 · Has a placebo group

Conditions studied: Atrial Fibrillation

In brief

The primary objective of this study is to evaluate the effect of ranolazine and of low-dose dronedarone when given alone and in combination at different dose levels on atrial fibrillation burden (AFB) over 12 weeks of treatment. AFB is defined as the total time a participant is in atrial tachycardia/atrial fibrillation (AT/AF) expressed as a percentage of total recording time.

Key facts

Study ID

NCT01522651

Run by

Gilead Sciences

People needed

134

Starts

2012-01-24

Expected to finish

2014-03-10

Last updated by the study team

2020-11-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Investigational Site — Beverly Hills, California, United States
• Investigational Site — Newport Beach, California, United States
• Investigational Site — San Francisco, California, United States
• Investigational Site — Aurora, Colorado, United States
• Investigational Site — Washington D.C., District of Columbia, United States
• Investigational Site — Lakeland, Florida, United States
• Investigational Site — Takoma Park, Maryland, United States
• Investigational Site — Towson, Maryland, United States
• Investigational Site — Utica, New York, United States
• Investigational Site — Cleveland, Ohio, United States
• Investigational Site — Warwick, Rhode Island, United States
• Investigational Site — Houston, Texas, United States
• Investigational Site — Murray, Utah, United States
• Investigational Site — Seattle, Washington, United States
• Investigational Site — Wausau, Wisconsin, United States
• Investigational Site — München, Bavaria, Germany
• Investigational Site — Würzburg, Bavaria, Germany
• Investigational Site — Bonn, North Rhine-Westphalia, Germany
• Investigational Site — Coburg, Germany
• Investigational Site — Frankfurt, Germany
• Investigational Site — Göttingen, Germany
• Investigational Site — Ingolstadt, Germany
• Investigational Site — Lübeck, Germany
• Investigational Site — Ashkelon, Ashqelon, Israel
• Investigational Site — Afula, Zefat, Israel

Full record on ClinicalTrials.gov

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