Gut Flora Dependent Metabolism of Dietary Phosphatidylcholine and Cardiovascular Disease

Completed · Early Phase 1

Conditions studied: Nutrition

In brief

The purpose of this study is to see if intestinal bacteria plays a role in choline metabolism (a form of choline monitored in this study is called phosphatidylcholine, also known as lecithin). This study will help to determine if choline metabolism is affected by short-term antibiotic therapy, and/or can be altered by probiotic therapy (e.g. in the form of eating yogurt).

Key facts

Study ID

NCT01519310

Run by

The Cleveland Clinic

People needed

4

Starts

2010-04-01

Expected to finish

2014-10-01

Last updated by the study team

2016-03-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women age 18 years or above.
• Able to provide informed consent and comply with study protocol

You may not qualify if…

• Significant chronic illness or end-organ dysfunction, including known history of heart failure, renal failure, pulmonary disease, or hematologic diseases.
• Active infection or received antibiotics within 2 months of study enrollment
• Use of OTC probiotic within past 2 months, or ingestion of yogurt within past month
• Chronic gastrointestinal disorders, or intolerance to probiotic therapy
• Allergies to eggs.

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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