A Study of Changes in Hepatic Function During Radiation Therapy Using Hepatobiliary Single Photon Emission Tomography (SPECT)

Completed

Conditions studied: Hepatocellular Carcinoma

In brief

Radiation-induced liver disease (RILD) is a syndrome characterized by the development of anicteric ascites approximately 2 weeks to 4 months after hepatic irradiation. Previous studies have shown that both the volume of liver irradiated and the dose of radiation delivered are prominent factors for development of RILD. While use of a population-based normal tissue complication probability model allows investigators to limit the risk of RILD to a clinically acceptable level, a test that permits investigators to determine an individual's risk of RILD during the course of treatment may allow for individualized treatment modifications, either to prevent toxicity or increase efficacy.

Key facts

Study ID

NCT01519232

Run by

University of Michigan Rogel Cancer Center

People needed

23

Starts

2008-08-01

Expected to finish

2014-05-01

Last updated by the study team

2015-05-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• cancer patients undergoing radiation of the Liver
• women and men who agree to avoid pregnancy
• life expectancy of at least 6 months

You may not qualify if…

• pregnant women
• breatsfeeding women
• prisoners

Where it is running

• University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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