A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss

Completed · Phase 1 · Has a placebo group

Conditions studied: Hearing Loss, Sensorineural

In brief

The objective of this study is to examine the safety, tolerability, and effects on hearing thresholds of two single doses of PF-04958242 and placebo in subjects with age-related hearing loss.

Key facts

Study ID

NCT01518920

Run by

Biogen

People needed

44

Starts

2011-12-01

Expected to finish

2013-02-01

Last updated by the study team

2019-11-21

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must have a current diagnosis of age related sensorineural hearing loss in the range of 30-60 dB, averaged over 2 and 4 kHz in at least one ear.
• Subjects must have symmetric hearing loss
• Subjects who can read, speak and comprehend English.

You may not qualify if…

• Subjects who have a history of sudden hearing loss and history or diagnosis of rapidly progressive idiopathic hearing loss
• Subjects who have hearing disorders other than age related sensorineural hearing loss
• Subjects with moderate or greater tinnitus
• Pregnant females; breastfeeding females; females of childbearing potential

Where it is running

• Pfizer Investigational Site — Anaheim, California, United States
• Pfizer Investigational Site — New Haven, Connecticut, United States
• Pfizer Investigational Site — New Haven, Connecticut, United States
• Pfizer Investigational Site — New Haven, Connecticut, United States
• Pfizer Investigational Site — New Haven, Connecticut, United States
• Pfizer Investigational Site — South Miami, Florida, United States
• Pfizer Investigational Site — Baltimore, Maryland, United States
• Pfizer Investigational Site — Dallas, Texas, United States
• Pfizer Investigational Site — Dallas, Texas, United States
• Pfizer Investigational Site — Dallas, Texas, United States
• Pfizer Investigational Site — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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