Reducing Radioisotope Dose: the Half-Dose CZT Study

Completed · Not applicable

Conditions studied: Coronary Artery Disease

In brief

This is a pilot study to see whether cardiac imaging can be performed using half the standard dose of radioisotope.

Key facts

Study ID

NCT01518777

Run by

S.M.Chang, MD

People needed

74

Starts

2012-01-01

Expected to finish

2016-12-16

Last updated by the study team

2019-09-06

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥ 18 years of age and referred for a clinically-indicated stress SPECT MPI study
• suspected or known coronary artery disease
• written informed consent

You may not qualify if…

• Evidence of a normal baseline scan after at least 50% of the protocol acquired baseline scans have been interpreted as being normal
• Participation in another investigational study within the preceding month
• Pregnant and/or breast-feeding female
• ECG evidence of left bundle branch block or paced rhythm
• Evidence of non-ischemic cardiomyopathy
• Presence of hypertrophic cardiomyopathy and/or severe valvular heart disease
• Severe claustrophobia or inability to lie flat for 20 minutes (the anticipated amount of time to complete the procedure)
• Known allergy to technetium-99m
• Potential contraindications to regadenoson use, due to severe lung disease; severe bradycardia (heart rate < 40 beats/min); second- or third degree atrioventricular heart block; sick sinus syndrome; long QT syndrome; severe hypotension; or decompensated heart failure.

Where it is running

• Houston Methodist Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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