Brown Fat Activity and White Fat Accumulation

Completed

Conditions studied: Hodgkins Lymphoma, Non-hodgkins Lymphoma

In brief

White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.

Key facts

Study ID

NCT01517581

Run by

Children's Hospital Los Angeles

People needed

32

Starts

2008-10-01

Expected to finish

2011-09-01

Last updated by the study team

2012-01-25

Who can join

Age: 6 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients had PET/CT scans with evidence of malignant disease
• Patients had no metabolically active BAT at diagnosis on their PET/CT scan
• Patients were disease free within 1 year of diagnosis

You may not qualify if…

• Patients had PET/CT scans with no evidence of malignant disease
• Patients with metabolically active BAT at diagnosis on their PET/CT scan
• Patients were not disease free within 1 year of diagnosis

Where it is running

• Children's Hospital Los Angeles — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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