Age-Related Changes in Body Composition
Stopped early
Conditions studied: Hypertension, Atherosclerosis
In brief
Background: \- Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age. Studies suggest that age-related inflammation may affect fatty tissue in the body. If this fat develops in the muscles or around the heart, it may increase risks of heart disease. Researchers will study body composition in older adults to see if age-related changes in body fat are related to higher risks of heart disease. Objectives: \- To study the relationship between fat deposits and aging, and greater risks of heart disease. Eligibility: * Participants in the Baltimore Longitudinal Study of Aging between 50 and 80 years of age. * Individuals between 50 and 80 years of age who have been diagnosed with coronary artery disease. Design: * Participants will be screened with a physical exam and medical history. * Participants will provide blood and urine samples. They will also have their height and weight measured. Waist circumference will also be taken. * Participants will have a DEXA scan to study their muscles. * Participants will have magnetic resonance imaging scans. These scans will study heart function and muscle and blood vessel health. * Participants with coronary artery disease will have catheterization. Blood samples will be collected during the procedure....
Key facts
- Study ID
- NCT01517113
- Run by
- National Institute on Aging (NIA)
- People needed
- 24
- Starts
- 2012-01-02
- Expected to finish
- 2017-10-13
- Last updated by the study team
- 2018-04-05
Who can join
Age: 50 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Known inflammatory disease
- Known liver disease
- Abnormal liver function tests defined by enzyme rise to greater than three times the upper limit of normal.
- Contraindications to the performance of MRI scans
- Chronic use of anti-inflammatory agents other than low dose aspirin (81mg). Chronic use is defined here as the inability to stop taking their anti-inflammatory agent for at least one week before starting this study
- Pregnant or lactating
- In addition, for BLSA participants:
- Known coronary artery disease by prior history, examination, or resting or stress electrocardiogram testing.
- In addition, for CAD participants undergoing arterial and hepatic vein inflammatory mediator sampling:
- Receiving therapy with heparin, a glycoprotein IIB/IIIA inhibitor, or bivalirudin
- History of atrial fibrillation
- Presence of an inferior vena cava filter
- Deep venous thrombosis
- Active infection.
Where it is running
- Johns Hopkins University — Baltimore, Maryland, United States
- National Institute of Aging, Clinical Research Unit — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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