Studying Motor Neuron Tests
Completed
Conditions studied: Healthy Subjects, Magnetic Resonance Imaging, Central Nervous System, Volunteer, Neurological Disorder
In brief
Background: \- People with motor neuron disorders have changes in the parts of the brain that control movement. Some tests that are currently used to study these changes are magnetic resonance imaging (MRI) and transcranial magnetic stimulation (TMS). We don t know if MRI scans and TMS give the same results if done at different times in the same person. Researchers want to see if these tests produce different results if given to healthy adults on two separate occasions. Objectives: \- To test the reliability of different tests of the brain used to study motor neuron disorders. Eligibility: * \<TAB\>Healthy individuals at least 35 years of age who have no history of neurological disorders and take no medications. * \<TAB\>Pregnant women may not participate. Design: * Participants will be screened with a medical history and physical exam. * Participants will have two testing visits 1 to 6 months apart. * The first visit will have three parts. The first part is a neurological exam to test strength, sensation, reflexes, and coordination of movement. The second part will be TMS tests. The third part will involve an MRI scan to study the parts of the brain that control movement. * At the second visit, participants will have MRI scanning only.
Key facts
- Study ID
- NCT01517087
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 47
- Starts
- 2012-02-01
- Expected to finish
- 2020-11-25
- Last updated by the study team
- 2021-03-12
Who can join
Age: 35 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Treatment within the preceding week with medications that affect neuronal excitability, such as antidepressants, sedatives, and drugs for epilepsy or migraine.
- Change in blood pressure medications within the preceding week.
- Metal in the body such as pacemakers, implanted pumps or other implanted electronic devices, some types of dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner or shrapnel fragments.
- Pregnancy. Women of childbearing potential will undergo urine pregnancy testing before MRI scanning.
- Fear of confined spaces.
- Serious medical illness.
- Employees or staff in the investigator's section.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.