Sodium Fluoride (NaF) Positron Emission Tomography/Computed Tomography (PET/CT) in Patients With Metastatic Castrate-resistant Prostate Cancer (CRPC) With Microtubule Directed Chemo or AR-directed Therapy

Completed

Conditions studied: Prostate Cancer

In brief

The purpose of this research study is to evaluate a newer imaging technique, called 18F-Sodium Fluoride (NaF) positron emission tomography (PET). NaF is a tracer (dye) that is very sensitive for changes in bone. By using this tracer with positron emission tomography/computed tomography (PET/CT) imaging, our ability to evaluate and measure changes in bone lesions could be greatly improved.

Key facts

Study ID

NCT01516866

Run by

University of Wisconsin, Madison

People needed

58

Starts

2011-11-01

Expected to finish

2018-01-01

Last updated by the study team

2019-11-18

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed adenocarcinoma of the prostate
• Identifiable prostate cancer-related bone metastases on bone scan in the spine, pelvis or other bone
• Patients must be starting a microtubule directed chemotherapy regimen for metastatic castrate-resistant prostate cancer OR
• Patients must be starting a AR-directed regimen (e.g. Abiraterone, MDV-3100, TAK-700, etc) for treatment of metastatic castrate-resistant prostate

You may not qualify if…

• Concurrent treatment with any other agent that is being used with the expressed purpose of treating of prostate cancer outside of the planned treatment regimen
• Patients who have received radiotherapy less than 4 weeks prior to registration.
• Patients who have received prior Strontium-89, Samarium-153, or other radioisotope.
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to sodium fluoride F-18 (NaF).

Where it is running

• National Cancer Institute — Bethesda, Maryland, United States
• Memorial Sloan Kettering — New York, New York, United States
• University of Wisconsin Carbone Cancer Center — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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