Non-invasive Quantification of Liver Iron With MRI

Completed

Conditions studied: Iron Overload, Hemosiderosis

In brief

The purpose of this study is to validate magnetic resonance imaging as a biomarker of hepatic iron concentration (HIC). Excessive accumulation of iron in the body is highly toxic, specifically in the liver. Accurate, non-invasive assessment of HIC is needed for diagnosis, quantitative staging and treatment monitoring or hepatic iron overload.

Key facts

Study ID

NCT01516853

Run by

University of Wisconsin, Madison

People needed

50

Starts

2012-01-01

Expected to finish

2015-06-01

Last updated by the study team

2019-12-06

Who can join

Age: 10 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Controls: 18 years or older with no known history of iron overload or liver disease.
• Patients: 10 years or older with known or suspected iron overload

You may not qualify if…

• Patients with contraindications to MRI (eg. pacemaker, contraindicated metallic implants, claustrophobia, etc) and pregnant females (as determined by self-report during MRI safety screening) will be excluded.
• For control subjects, those with known liver disease will be excluded.

Where it is running

• Wisconsin Institutes for Medical Research — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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