Photoprovocation Testing in Subjects With Cutaneous Lupus

Completed · Not applicable

Conditions studied: Lupus Erythematosus, Photosensitivity Conditions

In brief

Photosensitivity is well documented among lupus patients and is one of the diagnostic criteria for systemic lupus erythematosus (SLE). Photosensitivity is highly prevalent in lupus and has a wide range of clinical presentations. However, photosensitivity is a poorly defined in lupus and its pathogenesis is not well understood. The purpose of this study is to characterize the early clinical and histopathological changes in lupus skin that occur as a response to ultraviolet light.

Key facts

Study ID: NCT01516788
Run by: University of Pennsylvania
People needed: 19
Starts: 2011-12-01
Expected to finish: 2018-07-02
Last updated by the study team: 2021-07-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Participants who have a diagnosis of CLE based on either the Gilliam classification of DLE and SCLE, or SLE based on the American College of Rheumatology criteria.

You may not qualify if…

Participants who do not meet criteria for either CLE or SLE.
Participants with a diagnosis of Erythropoietic Protoporphyria and Solar Urticaria, or another photodermatoses other than Polymorphous light eruption.
Participants who are not yet 18 years old or who are not capable of giving written informed consent prior to enrolling in the study.
Participants who have undergone any recent phototesting, or phototherapy exposure, or those who are suspected of having a drug-induced photosensitivity.
Female participants who are pregnant or breastfeeding will be excluded from the study. This will be determined by patient self-reporting.

Where it is running

University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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