Associating Renal Transplantation With the ITN Signature of Tolerance

Completed

Conditions studied: Kidney Transplantation

In brief

This is an observational study for people who have received a kidney transplant within the past 1 to 5 years. Researchers in this study are looking for a certain pattern of genes and cells in the blood that has been found in a group of rare transplant patients who do not need immunosuppression. The study goal is to find out how common this pattern is in transplant patients, as a first step in determining if it can be used to personalize anti-rejection drug regimens better.

Key facts

Study ID

NCT01516177

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

250

Starts

2010-09-01

Expected to finish

2014-04-01

Last updated by the study team

2016-12-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Received first kidney transplant from a living or deceased donor.
• Kidney transplanted between 1 and 5 years ago.
• Calculated GFR of greater than or equal to 45 mL/min/1.73 m2 within last 6 months
• Ability to understand and provide informed consent.

You may not qualify if…

• History of steroid-resistant acute rejection
• History of two or more episodes of acute rejection
• Any acute rejection in the past year
• Current malignancy
• Transplant of another organ
• AIDS according to the CDC definition of AIDS.

Where it is running

• University of Alabama Birmingham — Birmingham, Alabama, United States
• University of California San Francisco — San Francisco, California, United States
• Emory University — Atlanta, Georgia, United States
• Northwestern University — Chicago, Illinois, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Mount Sinai School of Medicine — New York, New York, United States
• The Cleveland Clinic Foundation — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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