Inflammatory Response Following Intraarticular Fracture

Running, not enrolling

Conditions studied: Intraarticular Fracture and Post-traumatic Osteoarthritis

In brief

The purpose of the study is to investigate a relationship between the inflammatory response following intraarticular fracture and post-traumatic osteoarthritis. The investigators plan to evaluate the inflammatory cytokine profile in knee joint synovial fluid and blood serum in patients who sustain an intraarticular tibial plateau fracture and ankle joint synovial fluid and blood serum in patients who sustain an intraarticular tibial plafond fracture. This information will be combined with radiographs and patient outcome measures to determine a correlation between intraarticular inflammatory response and post-traumatic osteoarthritis.

Key facts

Study ID

NCT01514643

Run by

University of Utah

People needed

60

Starts

2011-10-01

Expected to finish

2028-12-01

Last updated by the study team

2026-04-29

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Radiographic evidence of tibial plateau fracture

You may not qualify if…

• Less than 18 years of age
• Greater than 60 years of age
• Any history of pre-existing knee osteoarthritis based on previous diagnosis or suggestive history
• Any history of autoimmune disease
• Any history of contralateral intra-articular knee injury

Where it is running

• University of Utah Orthopedics — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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