Investigation of Endothelium in Saphenous Vein Grafts
Completed · Not applicable
Conditions studied: Endothelial Function of Saphenous Vein Grafts
In brief
This is a single center prospective study of 30 patients undergoing elective heart bypass surgery (CABG) with at least two vein grafts from the leg (SVG). The purpose of this ex vivo study is to evaluate the function of vein grafts from small tissue samples treated with a pressure syringe and a non-pressure syringe. Syringes are routinely used to flush out the veins in preparation of bypass grafting. It is unknown if different levels of pressure in the syringe affect the vein or damage the vein. Small sections of tissue samples which are normally discarded will be obtained immediately after retrieval from the leg and before grafting to the heart. Tissue samples will be taken to the laboratory for study. There are no clinical endpoints in this study, however, clinical information will be obtained from the Society of Thoracic Surgeons database and will include demographics, risk factors, and perioperative outcomes.
Key facts
- Study ID
- NCT01510821
- Run by
- Emory University
- People needed
- 30
- Starts
- 2011-11-01
- Expected to finish
- 2012-06-01
- Last updated by the study team
- 2013-10-01
Who can join
Age: 21 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- patients undergoing elective coronary artery bypass graft surgery requiring at least 2 saphenous vein grafts
You may not qualify if…
- patients undergoing any concomitant surgical procedures
Where it is running
- Cardiothoracic Surgery Research Laboratory — Atlanta, Georgia, United States
- Emory University Hospital Midtown — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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