Triclosan, Triclocarban, and the Microbiota

Completed · Not applicable

Conditions studied: Triclosan Effects on Microbial Flora

In brief

Triclosan (5-chloro-2 (22,4-dichlorophenoxy)phenol) is a broad-spectrum antibacterial and antifungal agent that is found in thousands of common household products, including deodorants, toothpaste, "antibacterial" soaps, cleaning products, kitchen utensils, bedding, socks, trash bags. The benefits of triclosan have not been proven except in reducing plaque and gingivitis when used in toothpaste. In this study, the investigators intend to look at whether exposure to triclosan changes the colonizing flora of the skin, gut and mouth as well as changes in certain blood hormone levels, including adipocytokines, androgens, and inflammatory markers. Changes in the gut microbiota have been associated with a variety of disease states such as inflammatory bowel disease, colorectal cancer. Additionally, reductions in the microbiome diversity have been associated with obesity.

Key facts

Study ID

NCT01509976

Run by

Stanford University

People needed

20

Starts

2011-07-01

Expected to finish

2017-12-31

Last updated by the study team

2021-03-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Health subjects
• Age >18 years

You may not qualify if…

• Pregnancy
• Recent travel to the developing world (within 3 months)
• Recent use of antibiotics (within 3 months)
• Unwillingness to change personal care/hygiene products
• Recent gastrointestinal illness (within 3 months)
• Individuals who are unlikely to be available for the 10 months of the study period.

Where it is running

• Stanford University — Stanford, California, United States

Full record on ClinicalTrials.gov

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