Diesel Exhaust and Vascular Function
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Cardiovascular Effects
In brief
Double-blind, sham- and placebo-controlled randomized study of effects of freshly-generated diluted diesel exhaust inhalation on vascular function. To examine role of adrenergic system a trial of alpha-blocker terazosin is also used. Each participant completes four study sessions, separated by at least three weeks: 1) Diesel exhaust inhalation (DE, controlled at 300 micrograms/cubic meter for two hours) and terazosin (2 mg prior to inhalation exposure); 2) DE plus placebo (matched for terazosin); 3) filtered air plus terazosin; and 4) filter air plus placebo. The investigators assess outcomes of blood pressure, forearm brachial artery ultrasound, and plasma measures of endothelial activation. The investigators hypothesize that DE exposure will be associated with increased blood pressure, decreased brachial artery diameter, and increased circulating endothelins, and that these effects will be attenuated by terazosin administration.
Key facts
- Study ID
- NCT01508637
- Run by
- University of Washington
- People needed
- 24
- Starts
- 2012-01-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2015-08-03
Who can join
Age: 18 and older, up to 49. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- healthy without chronic illness
- Body Mass Index 18.5 - 26.0
- tolerates 2 mg terazosin dose without unacceptable symptoms
- able to return for four exposure sessions
You may not qualify if…
- any chronic disease
- tobacco user
- asthma
- elevated cholesterol
- obesity
- hypertension
- diabetes
- any chronic cardiovascular or pulmonary disease
- pregnancy or unwillingness to use effective contraception, if female
Where it is running
- University of Washington Medical Center — Seattle, Washington, United States (enrolling)
Full record on ClinicalTrials.gov
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