Double Push Acoustic Radiation Force (DP ARF) Ultrasound for Monitoring Degeneration in Duchenne Muscular Dystrophy

Completed

Conditions studied: Muscular Dystrophy, Duchenne

In brief

This is a pilot clinical trial to assess the ability of a new ultrasound-based imaging method, Double-Push Acoustic Radiation Force (DP ARF) ultrasound, to monitor the progression of Duchenne muscular dystrophy. The hypothesis being tested is that DP ARF ultrasound delineates changes in muscle composition and function in individual dystrophic muscles, from early through late stages of disease development, that correlate to time to loss of ambulation in patient volunteers.

Key facts

Study ID

NCT01506518

Run by

University of North Carolina, Chapel Hill

People needed

60

Starts

2012-01-01

Expected to finish

2020-05-31

Last updated by the study team

2021-08-02

Who can join

Age: 5 and older, up to 13. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of Duchenne muscular dystrophy with clinical onset by age 5
• Ability to stand, alone or with assistance, at time of enrollment
• Ability to communicate with pertinent staff
• Ability to understand and comply with study requirements
• Ability to give informed consent.

You may not qualify if…

• Confirmed diagnosis of other muscle disease
• Previous compartment syndrome
• Previous injury to selected limbs
• Previous vascular surgery to selected limbs
• History of a compressive neuropathy (e.g., sciatic, femoral or tibial palsy in leg)
• History of rhabdomyolysis

Where it is running

• The University of North Carolina at Chapel Hill Hospitals — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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