Airway Dimension Study in Children Undergoing MRI Sedated With Propofol and Dexmedetomidine

Stopped early · Phase 2

Conditions studied: Airway Remodeling

In brief

Sedation is required in infants and children to successfully complete MRI while maintaining respiratory and hemodynamic stability. Limited access to the patient may pose a safety risk during MRI examination. Therefore, appropriate drugs need to be selected, administered, and titrated to achieve these objectives. Propofol is commonly used for sedation in children in the MRI setting because of its predictability, rapid onset, and offset of action. Dexmedetomidine has sedative and analgesic properties without affecting cardiovascular and respiratory stability. The rationale of this research is to assess the effect of these drugs on the upper airway and validate their use in children with upper airway disorders.

Key facts

Study ID

NCT01505933

Run by

Milton S. Hershey Medical Center

People needed

24

Starts

2012-02-01

Expected to finish

2019-04-30

Last updated by the study team

2019-07-11

Who can join

Age: 2 and older, up to 5. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children undergoing MRI brain
• Age 2 - 5 yrs
• ASA I - II

You may not qualify if…

• OSA
• Pathology of upper airway
• Craniofacial anomalies
• Gastroesophageal reflux
• Increased intracranial pressure
• Body weight of 20% more than ideal
• Contraindication to the use of either drug
• Failure to maintain a patent airway during the study

Where it is running

• Penn State Hershey Medical Center — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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