Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis

Completed · Phase 3 · Has a placebo group

Conditions studied: Anterior Uveitis

In brief

The purpose of this study is to evaluate the safety and efficacy of ocular iontophoresis with dexamethasone phosphate ophthalmic solution EGP-437 using the EyeGate® II Drug Delivery System (EGDS) compared to prednisolone acetate ophthalmic suspension (1%) in patients with non-infectious anterior segment uveitis.

Key facts

Study ID

NCT01505088

Run by

Eyegate Pharmaceuticals, Inc.

People needed

193

Starts

2011-12-01

Expected to finish

2013-03-01

Last updated by the study team

2013-03-29

Who can join

Age: 12 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, age 12 to 85 years with a diagnosis of non-infectious anterior segment uveitis defined as an anterior chamber cell count of ≥ 11 cells
• Receive, understand, and sign a copy of the written informed consent form
• Be able to return for all study visits and willing to comply with all study-related instructions

You may not qualify if…

• Have uveitis of infectious etiology
• Have active intermediate or posterior uveitis
• Known positive HLA-B27 with a severe (4+) fibrinoid reaction
• Have previous anterior segment uveitis episode in the study eye ≤ 4 weeks prior to baseline visit
• Have used topical corticosteroid treatment in the study eye ≤ 48 hours prior to baseline visit
• Have used oral corticosteroid within the past 14 days prior to baseline
• Have received intravitreal or sub-Tenon corticosteroid treatment in the study eye within the past 6 months prior to baseline visit
• Currently using prescribed nonsteroidal anti-inflammatory agents (i.e., use of over-the-counter dosages is allowable) or prescribed immunosuppressive agents, unless the dose has been stable for the last six weeks and no change in dosing is anticipated for the duration of the study
• Have IOP ≥ 25 mmHg at baseline, a history of glaucoma, or require ocular anti-hypertensive medications in the study eye
• Be known steroid intraocular pressure responders in either eye
• Have open wounds/skin disease on the forehead area where the iontophoresis return electrode will be applied
• Have severe lesions of the eyelids or the ocular surface impeding the application of the iontophoresis applicator
• Have known allergy to dexamethasone or dexamethasone phosphate or any medication to be used in this study
• Have history or diagnosis of ocular herpes, corneal lesion of suspected herpetic origin, or Behçet's disease
• Have monocular or BCVA worse than 20/80 in the fellow eye
• Have optic neuritis of any origin
• Have clinically suspected or confirmed central nervous system or ocular lymphoma
• Planning to undergo elective ocular surgery during the study
• Have active hyphema, pars planitis, choroiditis, clinically significant macular edema, toxoplasmosis scar, or vitreous hemorrhage
• Have severe/serious ocular pathology or medical condition which may preclude study completion
• Have pacemaker and/or any other electrical sensitive support system
• Be pregnant or lactating female, or female of childbearing age and using inadequate birth control method
• Have participated in another investigational device or drug study within 30 days of baseline visit
• Have significant Fuch's Corneal Dystrophy

Where it is running

• Department of Ophthalmology at University of Alabama at Birmingham — Birmingham, Alabama, United States
• Arizona Eye Center — Chandler, Arizona, United States
• Associated Retina Consultants — Phoenix, Arizona, United States
• Retina-Vitreous Associates Medical Group — Beverly Hills, California, United States
• Doheny Eye Medical Group — Los Angeles, California, United States
• Orange County Retina Medical Group — Santa Ana, California, United States
• Colorado Retina Associates — Golden, Colorado, United States
• Corneal Consultants of Colorado — Littleton, Colorado, United States
• Connecticut Retina Consultants, LLC — Bridgeport, Connecticut, United States
• Eye Center of Southern Connecticut — Hamden, Connecticut, United States
• Yale Eye Center — New Haven, Connecticut, United States
• The Eye Associates of Manatee, LLP — Bradenton, Florida, United States
• Levenson Eye Associates — Jacksonville, Florida, United States
• Bascom Palmer Eye Institute — Miami, Florida, United States
• Logan Ophthalmic Research — Tamarac, Florida, United States
• Emory Eye Center — Atlanta, Georgia, United States
• Advanced Eye Care — Fort Oglethorpe, Georgia, United States
• Illinois Retina Associates — Chicago, Illinois, United States
• Raj K. Maturi, M.D. PC — Indianapolis, Indiana, United States
• Ellsworth Uveitis and Retina Care — Ellsworth, Maine, United States
• Wilmer Eye Institute — Baltimore, Maryland, United States
• Massachusetts Eye and Ear Infirmary — Boston, Massachusetts, United States
• Ophthalmic Consultants of Boston — Boston, Massachusetts, United States
• Massachusetts Eye Research and Surgery Institution — Cambridge, Massachusetts, United States
• Lifelong Vision Foundation — Chesterfield, Missouri, United States

Full record on ClinicalTrials.gov

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