Effects of a Combined Transcranial Magnetic Stimulation (TMS) and Cognitive Training in Alzheimer Patients

Completed · Not applicable · Has a placebo group

Conditions studied: Alzheimer's Disease

In brief

This study looks at the potential benefits of combining cognitive training (mental exercises) together with transcranial magnetic stimulation (also known as TMS) to see if this can make a difference in the condition of people with Alzheimer's disease by improving their disease and the cognitive decline that goes along with it.

Key facts

Study ID

NCT01504958

Run by

Beth Israel Deaconess Medical Center

People needed

22

Starts

2010-12-01

Expected to finish

2015-05-01

Last updated by the study team

2017-07-02

Who can join

Age: 55 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female age 55-90
• Diagnosed with mild to moderate AD according to DSM-IV criteria
• Diagnosis of dementia of the Alzheimer's type according to the criteria established by the NINCDS-ADRDA
• Normal or corrected normal ability to see and hear
• Primary language is English

You may not qualify if…

• IQ below 85
• Any major structural abnormalities on MRI (eg. Infarction, intracerebral malformation)
• Any symptoms of disease or abnormalities sufficient to cause memory impairment other than AD (eg. Normal pressure hydrocephalus, progressive supranuclear palsy)
• Any functional psychiatric disorder (eg. Schizophrenia)
• Chronic uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (eg. Cardiac malformation)
• History of seizures, diagnosis of epilepsy
• Metal implants excluding dental fillings or any of the following medical devices: pacemaker, implanted medication pump, vagal nerve stimulator, deep brain stimulator, TENS unit (unless removed completely for this study), cerebral spinal fluid shunt
• Recent withdrawal from the following drugs: alcohol, barbiturates, benzodiazepines, meprobamate, chloral hydrate

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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