Study to Assess Effect of Cyclosporine on the Blood Levels of Ticagrelor

Completed · Phase 1

Conditions studied: Healthy

In brief

The purpose of this study is to assess the effect of Cyclosporine on the blood levels of Ticagrelor.

Key facts

Study ID

NCT01504906

Run by

AstraZeneca

People needed

20

Starts

2012-01-01

Expected to finish

2012-06-01

Last updated by the study team

2012-12-12

Who can join

Age: 18 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Provision of signed and dated written informed consent prior to any study-specific procedures
• Healthy male subjects aged 18 to 45 years (inclusive) with suitable veins for cannulation or repeated venipuncture

You may not qualify if…

• History or presence of gastrointestinal, hepatic or renal disease, or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs
• A history of hemophilia, von Willebrand's disease, lupus anti-coagulant, or other diseases/syndromes that can either alter or increase the propensity for bleeding
• A personal history of vascular abnormalities including aneurysms; a personal history of severe hemorrhage, hematemesis, melena, hemoptysis, severe epistaxis, severe thrombocytopenia, intracranial hemorrhage, or rectal bleeding within 1 year

Where it is running

• Research site — Overland Park, Kansas, United States

Full record on ClinicalTrials.gov

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