Atrioventricular Valve Regurgitation Vena Contracta; Echo Versus MRI
Completed
Conditions studied: Tricuspid Valve Regurgitation, Non-rheumatic, Mitral Valve Regurgitation
In brief
The purpose of this pilot study is to evaluate mitral (left atrioventricular valve) and tricuspid (right atrioventricular valve (AVV)) regurgitation using cardiac magnetic resonance imaging (CMR) as the non-invasive "gold standard" compared to transthoracic echocardiography (TTE) to evaluate measurements of the width of the regurgitation jet (vena contracta (VC)) to demonstrate the utility of the VC as a means to objectively evaluate atrioventricular valve regurgitation. In addition, feasibility and other quantitative and qualitative measures of regurgitation will be compared between CMR and TTE. * Hypothesis 1: The ability to objectively evaluate atrioventricular valve regurgitation and VC width with TTE and CMR has a high feasibility rate with acceptable intra and inter-observer variability by two independent readers. * Hypothesis 2: There will be positive correlation between the TTE measurement of the VC width and quantitative assessment of atrioventricular valve regurgitation by TTE and CMR. * Hypothesis 3: There will be a positive correlation between the quantitative measurements of atrioventricular valve regurgitation by phase contrast velocity encoded CMR with quantitative values as measured by TTE. * Hypothesis 4: There will be a positive correlation between qualitative assessment of atrioventricular valve regurgitation by CMR compared to TTE.
Key facts
- Study ID
- NCT01504880
- Run by
- Medical College of Wisconsin
- People needed
- 3
- Starts
- 2010-06-01
- Expected to finish
- 2019-12-19
- Last updated by the study team
- 2020-02-06
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Audible AV valve regurgitation on clinical exam, as noted by most recent clinic note.
- Clinically indicated CMR study scheduled and have had an echocardiogram in the last 6 months
You may not qualify if…
- Poor quality CMR study
- Unable to complete a CMR
- Have a contraindication to CMR scan (e.g., pregnancy, pacemaker or defibrillator presence, unable to hold still within scanner for imaging)
- Common AV valve
- Corresponding semilunar valve regurgitation which precludes use of stroke volume comparison as a second means of assessing AVV regurgitation by CMR
- Intracardiac shunts which precludes use of stroke volume comparison as a second means of assessing AVV regurgitation by CMR.
Where it is running
- Children's Hospital of Wisconsin — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
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