Effect of a Component of Fish Oil on Exercise-Induced Bronchoconstriction and Airway Inflammation in Asthma

Completed · Not applicable · Has a placebo group

Conditions studied: Asthma, Exercise-Induced Bronchoconstriction

In brief

The primary aim of this study will be to evaluate the effects of Lyprinol® supplementation on airway inflammation and the bronchoconstrictor response to dry air hyperpnea in individuals with asthma. The investigators hypothesize that Lyprinol® supplementation, compared to placebo, will significantly attenuate airway inflammation and hyperpnea-induced bronchoconstriction in asthmatic individuals.

Key facts

Study ID

NCT01504646

Run by

Indiana University

People needed

20

Starts

2012-01-01

Expected to finish

2012-08-01

Last updated by the study team

2018-10-23

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have been diagnosed with asthma and EIB. Evidence of a diagnosis of asthma will include medication use as well as history and symptoms as outlined in the NHLBI Guidelines for the Diagnosis and Management of Asthma. For the diagnosis of EIB, subjects must demonstrate a fall in FEV1 of ≥ 10% after dry air eucapnic voluntary hyperventilation (EVH), a simulated exercise challenge; FEV1 is a measure of lung function
• Not currently be taking any fish oil supplements
• Limit their fish consumption to 1 fish meal per week during the course of the study

You may not qualify if…

• Severe asthma is indicated. These subjects will be identified by a post-EVH drop in FEV1 that is greater than 50% during their first lab testing session or will have a history of severe asthma-related events such as hospitalizations or emergency room visits. Only mild to moderate asthmatics (i.e. subjects whose FEV1 drops by 10-50%) will be included in this study.
• They taking currently taking asthma maintenance medications
• They are pregnant
• They have a history of hyperlipidemia (high cholesterol), hypertension, diabetes, bleeding disorder, delayed clotting time, or seizure disorder
• They are allergic to shellfish, fish, corn, or soy products

Where it is running

• Indiana University School of Health, Physical Education, and Recreation — Bloomington, Indiana, United States

Full record on ClinicalTrials.gov

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