Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism

Completed · Not applicable

Conditions studied: Obstructive Sleep Apnea, Sleep Apnea, Sleep-disordered Breathing

In brief

Obstructive sleep apnea affects approximately 2-4% of middle-aged adults in the general population and is associated with several medical conditions including hypertension and coronary artery. Research over the last decade has shown that obstructive sleep apnea may also increase the propensity for insulin resistance, glucose intolerance, and type 2 diabetes mellitus. Positive airway pressure (PAP) is the first line therapy for the treatment of obstructive sleep apnea. While PAP therapy has several favorable effects such as improvements in daytime sleepiness and quality of life, it is not clear whether using PAP therapy can alter metabolic risk. The overall objective of this study is to examine whether treatment of obstructive sleep apnea with positive airway pressure therapy improves glucose tolerance and insulin sensitivity. The primary hypothesis of this study is that PAP therapy of obstructive sleep apnea will improve in insulin sensitivity and glucose metabolism.

Key facts

Study ID

NCT01503164

Run by

Johns Hopkins University

People needed

111

Starts

2011-09-01

Expected to finish

2013-12-01

Last updated by the study team

2017-10-19

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to give informed consent
• Obstructive sleep apnea (untreated)
• Ability to comply with study-related assessments

You may not qualify if…

• Inability to consent or commit to the required visits
• Diabetes mellitus (fasting glucose > 126 mg/dl)
• Use of insulin or oral hypoglycemic agent
• Weight change of 10% in last six months
• Use of oral steroids in the last six months
• Severe pulmonary disease (i.e., COPD)
• Renal or hepatic insufficiency
• Recent Myocardial Infarction (MI) or stroke (< 3 months)
• Occupation as a commercial driver
• Active substance use
• Untreated thyroid disease
• Pregnancy
• Anemia (Hematocrit < 30%)
• Any history of seizures or other neurologic disease
• Poor sleep hygiene or sleep disorder other than sleep apnea
• Excessive subjective sleepiness (Epworth score > 18)

Where it is running

• Johns Hopkins Bayview Medical Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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