Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy

Completed · Not applicable

Conditions studied: Brain Neoplasm, Recurrent Brain Neoplasm

In brief

This randomized clinical trial studies how well an adaptive computerized cognitive training program works compared to a non-adaptive computerized cognitive training program in treating younger patients with brain tumor who underwent radiation therapy. Providing a computer training program may improve the well-being and quality of life of patients with cognitive (physical and mental) function difficulties caused by radiation therapy to the brain.

Key facts

Study ID

NCT01503086

Run by

Children's Oncology Group

People needed

45

Starts

2014-07-30

Last updated by the study team

2026-04-23

Who can join

Age: 6 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient must be newly diagnosed or relapsed/progressed with a brain tumor that has not previously been treated with CRT
• Note: COG therapeutic study participation is not required for ACCL10P1 enrollment
• Patient enrollment must occur within 4 calendar months following completion of CRT
• Reminder: after patient enrollment, baseline testing followed by randomization must occur within 2-4 months after completion of CRT
• The patient must have an identified caregiver who is willing and able to oversee the training practice during the intervention period (ie, for 5-9 weeks starting approximately 3 months after completion of CRT)
• The patient must have access to a telephone and phone number where they can be reached
• The patient and caregiver must have reading, speaking and listening comprehension of English
• All patients and/or their parents or legal guardians must sign a written informed consent (patient assent is also recommended when applicable according to each institution's policy)
• All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

You may not qualify if…

• Patients with pontine glioma are not eligible
• Patients with an estimated survival of less than one year are not eligible
• Patients with a history of traumatic brain injury prior to tumor diagnosis are not eligible
• Patients with a motor, visual, or auditory handicap that prevents computer use (e.g., unresolved posterior fossa syndrome) are not eligible to participate in this trial
• Patients with full-scale intelligence quotient (IQ) < 70 per previous testing OR existing diagnosis of/educational classification as a student with an intellectual disability are not eligible

Where it is running

• Children's Hospital Colorado — Aurora, Colorado, United States
• Alfred I duPont Hospital for Children — Wilmington, Delaware, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Broward Health Medical Center — Fort Lauderdale, Florida, United States
• Golisano Children's Hospital of Southwest Florida — Fort Myers, Florida, United States
• Nemours Children's Clinic-Jacksonville — Jacksonville, Florida, United States
• Nemours Children's Hospital — Orlando, Florida, United States
• Tampa General Hospital — Tampa, Florida, United States
• Children's Healthcare of Atlanta - Arthur M Blank Hospital — Atlanta, Georgia, United States
• Saint Luke's Cancer Institute - Boise — Boise, Idaho, United States
• Blank Children's Hospital — Des Moines, Iowa, United States
• C S Mott Children's Hospital — Ann Arbor, Michigan, United States
• Children's Mercy Hospitals and Clinics — Kansas City, Missouri, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Albany Medical Center — Albany, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• East Tennessee Childrens Hospital — Knoxville, Tennessee, United States
• Saint Jude Children's Research Hospital — Memphis, Tennessee, United States
• UT Southwestern/Simmons Cancer Center-Dallas — Dallas, Texas, United States
• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
• VCU Massey Comprehensive Cancer Center — Richmond, Virginia, United States
• Seattle Children's Hospital — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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