Stroke Study: Operative Strategies to Reduce Cerebral Embolic Events During Coronary Artery Bypass Surgery
Completed · Not applicable
Conditions studied: Stroke
In brief
One of the most devastating complications of coronary artery bypass surgery (CABG) is postoperative stroke. While there are multiple causes of stroke after CABG, particles generated during handling of the aorta is believed to account for most neurologic effects. Handling of the aorta during CABG occurs several times during the operation. One strategy to reduce aortic handling is to avoid cardiopulmonary bypass altogether by using off-pump techniques (OPCAB). Another method is to avoid the use of aortic clamps and/or to use devices that do not require aortic clamping. This study will test the hypothesis that an off-pump (OPCAB) approach and devices to perform clampless surgery will result in the least amount of aortic handling and therefore the lowest incidence and frequency of neurologic adverse events.
Key facts
- Study ID
- NCT01502683
- Run by
- Emory University
- People needed
- 193
- Starts
- 2011-12-01
- Expected to finish
- 2016-12-01
- Last updated by the study team
- 2017-01-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- > 18 years
- undergoing primary isolated coronary artery bypass surgery
- ability to sign informed consent
You may not qualify if…
- history of preoperative stroke
- reoperative cardiac surgery
- salvage or emergency CABG
- known left ventricular or left atrial thrombus
- concomitant valvular or aortic surgery
Where it is running
- Emory University Hospital Midtown — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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