Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients

Completed · Phase 4

Conditions studied: Hypertension

In brief

The purpose of this study is to determine if Nebivolol improves microvascular perfusion in skeletal muscle during exercise in hypertensive patients and whether this improvement is accompanied by reduction in vascular oxidative stress or increased endothelial nitric oxide synthase (eNOS) expression in humans.

Key facts

Study ID

NCT01501929

Run by

University of Texas Southwestern Medical Center

People needed

32

Starts

2010-08-01

Expected to finish

2015-12-01

Last updated by the study team

2018-11-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women with stage I primary untreated hypertension (BP between 140-159/90-99 mmHg)
• Age 18-65

You may not qualify if…

• Congestive heart failure
• Coronary artery disease
• Left ventricular hypertrophy by echocardiography or ECG
• History of stroke
• Average blood pressure >159/99 mmHg
• Bradycardia with a resting heart rate <55 bpm
• Chronic kidney disease with a serum creatinine > 1.4 mg/dL
• Asthma or chronic obstructive pulmonary disease
• Women who are pregnant or planning to become pregnant
• Hypersensitivity to beta blockers, hydrochlorothiazide, or Definity
• Any history of substance abuse (other than tobacco)
• Concomitant drug treatment which raises endogenous nitric oxide levels, including nitrates or phosphodiesterase V inhibitors (Viagra, Levitra)
• History of symptomatic bradycardia or heart block
• Patients with Right-to-left, bidirectional, or transient right-to-left cardiac shunts
• Hypersensitivity to perflutren, blood, blood products or albumin.

Where it is running

• UT Southwestern Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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