Cabazitaxel Compared to Topotecan for the Treatment of Small Cell Lung Cancer

Completed · Phase 2

Conditions studied: Small Cell Lung Cancer

In brief

Primary Objective: To demonstrate progression free survival (PFS) improvement for cabazitaxel compared to topotecan in participants with sensitive or resistant/refractory small cell lung cancer following a first line platinum based chemotherapy. Secondary Objectives: * To assess disease progression free rate at 12 weeks * To assess Response Rate (Response Evaluation Criteria in Solid Tumor \[RECIST\] 1.1) and duration of response * To assess Overall Survival (OS) * To assess the Safety (National Cancer Institute - Common Toxicity Criteria \[NCI-CTC\] version 4.03) * To assess the Health-Related Quality of Life (HRQoL)

Key facts

Study ID

NCT01500720

Run by

Sanofi

People needed

179

Starts

2012-03-01

Expected to finish

2014-04-01

Last updated by the study team

2015-04-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histological/cytological proven locally advanced or metastatic small cell lung cancer with progressive disease during or after first line platinum based chemotherapy
• Male or female greater than or equal to (>=) 18 years (or country's legal age of majority if greater than [>]18 years)
• Participants with measurable disease, Response Evaluation Criteria in Solid Tumors (RECIST) (version 1.1)
• Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to (<=) 1

You may not qualify if…

• Absence of signed and dated Institutional Review Board (IRB)-approved participant informed consent form prior to enrollment into the study
• More than one prior chemotherapy regimen. Prior treatment with topotecan or taxanes
• Less than 28 days elapsed from prior treatment with chemotherapy, radiotherapy or surgery to the time of randomization (Radiotherapy for bone pain palliation is allowed)
• Adverse events (excluding alopecia) from any prior anticancer therapy of grade >1 (National Cancer Institute Common Terminology Criteria [NCI CTCAE] v4.03) at the time of randomization
• Uncontrolled Central Nervous System (CNS) metastases: participants with CNS metastases may have previous irradiation, only participants with stable disease or response to irradiation who are without CNS symptoms and on a maximum steroid dose of dexamethasone 8 mg daily or equivalent could be included
• Participants with known leptomeningeal metastases
• History of other, invasive neoplasm requiring ongoing therapy
• Participation in another clinical trial and any concurrent treatment with any investigational drug within 30 days prior to randomization
• Any of the following within 6 months prior to study enrollment: myocardial infarction, severe/unstable angina pectoris, coronary/peripheral artery bypass graft, New York Heart Association class III or IV congestive heart failure, stroke or transient ischemic attack
• Any severe acute or chronic medical condition, which could impair the ability of the participant to participate in the study or interfere with interpretation of study results
• Known Human Immunodeficiency Virus (HIV) disease, or active hepatitis B or C (systematic testing was not required)
• Pregnant or breast-feeding woman. Positive serum or urine pregnancy test prior to randomization
• Participant with reproductive potential (M/F) who did not agree to use an accepted and effective method of contraception during the study treatment period and for at least 6 months after the completion of the study treatment. The definition of "effective method of contraception" was based on the investigator's judgment. Effective method of contraception should also be adapted to local regulation
• History of hypersensitivity to polysorbate 80
• Inadequate organ and bone marrow function as evidenced by:
• Hemoglobin less than [<] 9.0 gram per deciliter (g/dL)
• Absolute neutrophil count <1.5 x 10\^9 per liter
• Platelet count <100 x 10\^9 per liter
• Aspartate Aminotransferase/Serum Glutamic Oxaloacetic Transaminase (AST/SGOT) and/or alanine aminotransferase/Serum Glutamic-Pyruvic Transaminase (ALT/SGPT) >2.5 x Upper Limit of Normal (ULN)
• Alkaline Phosphatase (AP) >2.5 x ULN. In case of liver metastases AP >5 x ULN
• Total bilirubin >1.0 x ULN
• Serum Creatinine >1.5 x ULN. If creatinine 1.0 - 1.5 x ULN, creatinine clearance will be calculated according to Chronic Kidney Disease Epidemiology Collaboration formula, and creatinine clearance <60 milliliter per minute (mL/min) was exclude the participant.
• The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.

Where it is running

• Investigational Site Number 840005 — Omaha, Nebraska, United States
• Investigational Site Number 840006 — Lebanon, New Hampshire, United States
• Investigational Site Number 840003 — Middletown, Ohio, United States
• Investigational Site Number 840001 — Philadelphia, Pennsylvania, United States
• Investigational Site Number 076001 — Porto Alegre, Brazil
• Investigational Site Number 124003 — Montreal, Canada
• Investigational Site Number 124002 — Oshawa, Canada
• Investigational Site Number 124004 — Rimouski, Canada
• Investigational Site Number 124001 — Toronto, Canada
• Investigational Site Number 152001 — Santiago, Chile
• Investigational Site Number 152005 — Santiago, Chile
• Investigational Site Number 250005 — Brest, France
• Investigational Site Number 250004 — Caen, France
• Investigational Site Number 250006 — La Tronche, France
• Investigational Site Number 250002 — Lille, France
• Investigational Site Number 250003 — Saint-Herblain, France
• Investigational Site Number 250007 — Villejuif, France
• Investigational Site Number 276003 — Großhansdorf, Germany
• Investigational Site Number 276006 — Löwenstein, Germany
• Investigational Site Number 300005 — Athens, Greece
• Investigational Site Number 300003 — Athens, Greece
• Investigational Site Number 300001 — Heraklion, Greece
• Investigational Site Number 300002 — Thessaloniki, Greece
• Investigational Site Number 300004 — Thessaloniki, Greece
• Investigational Site Number 840007 — Muscle Shoals, Alabama, United States

Full record on ClinicalTrials.gov

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